Mthwakazi is known for her completely unique "Xho-pera" performances, which combine classical operatic vocals, exclusively in her native isiXhosa, with ancestral sounds from indigenous stringed bows and percussion instruments. 

Mthwakazi's compositions shift back and forth through time, gathering elements of traditional African, choral and church music, jazz, funk and a range of genres.   Contemporary instrumentation (keys, bass, brass) adds another layer, and she plays with a formation that ranges from a duo through to a full orchestra, or “Xhochestra”, depending on the occasion.    

Mthwakazi draws on a distinguished career of more than 20 years, which saw her perform in SA and Europe as a Mezzo Soprano, Coloratura, Dramatic Soprano and Lyric Soprano with top ensembles including  Isango-Portobello, the Olivier Award-winning Opera Company. 

Mthwakazi herself is an internationally recognised bow music expert, and plays a variety of bow instruments such as uHadi, uMrhubhe & uMakhweyane, many of which she makes by hand.   She has performed alongside legendary artists such as the late Dr Sibongile Khumalo, Hugh Masekela,  Madosini, Queen Cora, Simphiwe Dana and Jonas Gwangwa.

Mthwakazi is deeply rooted in her Eastern Cape heritage, and her electrifying performances, with extravagant headdresses, painted face designs and designed costumes, evoke images akin to visions. Her music carries a message which emphasizes spirituality, humanity, humility, peace, optimism, unity, co-existence and progress as a way of living.